Protein losing nephropathy, glomerulonephritis, and uremic gastritis in a 3 year old MI Labrador Retriever

History

A 3-year-old male Labrador Retriever dog was presented for anorexia and weight loss. CBC was within normal limits, however blood chemistry showed hyperproteinemia, hypoalbuminemia, low albumin/globulin ratio, marked azotemia, hyperphosphatemia, mild hypocalcemia, hyperkalemia, and hyperamylasemia. T4 was within normal range. The urine had a cloudy appearance; 3+ proteinuria and 3+ hematuria were present on urinalysis.

A 3-year-old male Labrador Retriever dog was presented for anorexia and weight loss. CBC was within normal limits, however blood chemistry showed hyperproteinemia, hypoalbuminemia, low albumin/globulin ratio, marked azotemia, hyperphosphatemia, mild hypocalcemia, hyperkalemia, and hyperamylasemia. T4 was within normal range. The urine had a cloudy appearance; 3+ proteinuria and 3+ hematuria were present on urinalysis.

Clinical Differential Diagnosis

Renal disease – acute, chronic, congenital, pyelonephritis, neoplasia. Nephrotic syndrome. Primary glomerulonephritis with secondary renal failure

DX

Protein-losing nephropathy, glomerulonephritis, uremic gastritis

Sampling

None

Sonographic Differential Diagnosis

Glomerulonephritis – protein losing nephropathy. Suspect Lyme nephritis, or similar immune complex disease. Uremic gastritis.

Image Interpretation

The kidneys present thickened and uniformly echogenic cortices that are hypervascular on power Doppler evaluation. Slight pyelectasia is present due either to fluid therapy (< 0.3 cm) or due to infection (pyelonephritis). The gastric wall is edematous and uniformly thickened consistent with gastritis.

Outcome

The patient was euthanized due to financial concerns and poor prognosis.

Video

Patient Information

Patient Name : Jessie M
Age : 3 Years
Gender : Male, Intact
Species : Canine
Liz Wuz Here : Yes
Status : Complete
Code : 06_00022

Blood Chemistry

  • Albumin, Low
  • Albumin/Globulin Ratio, Low
  • Amylase, High
  • Azotemia
  • BUN high
  • Calcium, High
  • Calcium, Low
  • Creatinine, High
  • Phosphorus, High
  • Potassium, High
  • Total Protein, High

Clinical Signs

  • Anorexia
  • Weight loss

Urinalysi

  • Appearance Turbid
  • Blood Present
  • Protein Present

Images

LeftKidney

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