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Questions about the MDR1 Gene in Collies.

Hello all, I am working on a basic neuter estimate for an 11-month-old Collie and the MDR1 medicine toxicity keeps popping into my head.  We routinely give our spays and neuters an injection of Rimadyl post-operatively. 

  • I haven’t had a Collie come across my surgical table in  awhile, but aside from the Ivermectin toxicity issue if they have the mutant gene, what other medications can cause toxicity? Is Rimadyl one of them?
  • If you search online all I can find is breeder information on it, which
    I find is not always true medical fact. Thanks!  🙂


Hello all, I am working on a basic neuter estimate for an 11-month-old Collie and the MDR1 medicine toxicity keeps popping into my head.  We routinely give our spays and neuters an injection of Rimadyl post-operatively. 

  • I haven’t had a Collie come across my surgical table in  awhile, but aside from the Ivermectin toxicity issue if they have the mutant gene, what other medications can cause toxicity? Is Rimadyl one of them?
  • If you search online all I can find is breeder information on it, which
    I find is not always true medical fact. Thanks!  🙂

KV CVT SonoPath

6 responses to “Questions about the MDR1 Gene in Collies.”

  1. These drugs have been report
    These drugs have been report to MDR1 mutated dogs -Acepromazine, butorphanol, emodepside, erythromycin, loperamide, selamectin, milbemycin, moxidectin, vincristine, vinblastine, doxorubicin. The NSAIDs do not require P-glycoprotein.

  2. These drugs have been report
    These drugs have been report to MDR1 mutated dogs -Acepromazine, butorphanol, emodepside, erythromycin, loperamide, selamectin, milbemycin, moxidectin, vincristine, vinblastine, doxorubicin. The NSAIDs do not require P-glycoprotein.

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